Denosumab Active Against Giant Cell Tumor of Bone 02/11/2010
In a Phase II clinical trial, denosumab produced high rates of tumor response among patients with recurrent or unresectable giant cell tumors of bone. These results were published in Lancet Oncology. Denosumab is an investigational drug that targets a protein known as the RANK ligand. This protein regulates ...

Denosumab More Effective than Zometa® in Patients with Bone Metastases 07/08/2009
Among women with bone metastases from breast cancer, the investigational drug denosumab was more effective than Zometa® (zoledronic acid) at reducing the risk of bone complications such as fracture. The results of this Phase III clinical trial were made available in a press release from Amgen. Metastatic cancer refers to cancer ...

Denosumab Produces Promising Results Against Giant Cell Tumor of the Bone 06/05/2009
Denosumab Produces Promising Results Against Giant Cell Tumor of the Bone In a Phase II clinical trial, 86% of patients with giant cell tumor of the bone responded to treatment with the investigational targeted therapy denosumab. These results were presented at the 2009 annual meeting of the American Society of Clinical ...

Chemotherapy Combination Produces Promising Results in Ewing's Sarcoma 04/05/2006
Among patients with high-risk Ewing's sarcoma family of tumors (ESFT), treatment with an intensified chemotherapy regimen of ifosfamide, carboplatin, and etoposide (ICE) plus cyclophosphamide, doxorubicin, and vincristine (CAV) resulted in good control of disease and made it easier to perform surgery. These results were published in the journal Cancer. The ...

Cisplatin Benefits Patients with Metastatic Osteosarcoma 01/12/2006
A comparison of two clinical trials suggests that the chemotherapy drug cisplatin is more effective against metastatic osteosarcoma than the chemotherapy drug carboplatin. These results were published in the journal Cancer. Osteosarcoma is a type of cancer that originates in the bone. Patients with osteosarcoma are often young; the disease ...

Type of Treatment Influences Survival with Radiation-Induced Osteosarcoma 12/02/2005
Aggressive treatment appears to significantly improve survival among patients who develop radiation-induced osteosarcoma following treatment of childhood cancer, according to a study published in the International Journal of Radiation Oncology, Biology, Physics. Osteosarcoma is a type of cancer that originates in the bone. Standard treatment for osteosarcoma depends largely on ...

Osteosarcoma Patients with Recurrent Lung Metastases May Benefit from Additional Surgery 11/16/2005
Osteosarcoma frequently spreads to the lungs, and in some cases these lung metastases can be surgically removed. When the lung metastases recur after surgery, additional lung surgery may be warranted, according to a study published in the journal Cancer . Osteosarcoma is a type of cancer that originates in the ...

Intra-Arterial Chemotherapy May Improve Survival in Osteosarcoma 09/12/2005
According to a recent article published in the journal Clinical Orthopaedics and Related Research, intra-arterial chemotherapy prior to surgery may improve survival in young patients with osteosarcoma of the extremity. Osteosarcoma is a type of cancer that originates in the bone. Patients with osteosarcoma are often young; the disease most ...

Short and Long Courses of Radiation Reduce Bone Pain 06/17/2005
A recent article in the Journal of the National Cancer Institute reports that a short course of radiation is equally effective as a standard 10-course treatment for relieving the pain associated with bone metastases. Bone metastases occur when cancer from another site spreads to the bones. The many possible sources ...