Rectal Cancer Increasing in People Under 40 09/01/2010
Although still relatively uncommon in young people, the incidence of rectal cancer appears to be increasing in this population. These results were published in the journal Cancer. Colorectal cancer is the second leading cause of cancer death in the United States. The colon is the first 4 to 5 feet of ...

Pathological Complete Response Predicts Better Outcomes in Locally Advanced Rectal Cancer Patients 08/24/2010
Among patients with locally advanced rectal cancer, a complete disappearance of detectable cancer (pathological complete response) after preoperative chemoradiation therapy is linked with better long-term outcomes. These findings were recently published in the journal The Lancet Oncology.[1] Rectal cancer is a disease in which malignant cells arise from the cells ...

Antibiotic Sponge Ineffective at Preventing Surgical Infection 08/11/2010
Patients undergoing colorectal surgery are reported to experience an increased incidence of surgical-site infection with the addition of a gentamicin-collagen sponge enclosed at the surgery site. These findings were recently published in the New England Journal of Medicine.[1] Colon cancer is the fourth most commonly diagnosed cancer in the United ...

Radioembolization plus Fluorouracil Active in Colorectal Cancer Patients with Liver Metastases 07/01/2010
Radioembolization plus the chemotherapy agent fluorouracil slows cancer progression for colorectal cancer patients whose disease has progressed following prior treatment with chemotherapy and have metastases limited to the liver. These findings were recently published in the Journal of Clinical Oncology.[1] Colorectal cancer is the second leading cause of cancer-related deaths ...

Depression May Persist With Metastatic Cancer 05/26/2010
A substantial number of patients with metastatic cancer may suffer from depression which tends to persist and grow more severe toward the end of life, according to the results of a study published early online in the Journal of Clinical Oncology.[1] While cancer and other serious illnesses are risk factors ...

Rates of Adenoma Detection Linked to Risk of Interval Colorectal Cancer 05/17/2010
Endoscopists who detect tumors or polyps (adenomas) at a higher rate during colonoscopy screening for colorectal cancer tend to produce a lower risk for interval cancer among their patients, according to a study published in the New England Journal of Medicine. Colon cancer is the second leading cause of cancer death ...

Colorectal Cancer Screening with Flexible Sigmoidoscopy Reduces Incidence and Death 05/06/2010
Among individuals between 55 and 64 years of age, one screening using flexible sigmoidoscopy can reduce risk of developing colorectal cancer and dying from the disease, according to a study published in The Lancet. Colon cancer is the second leading cause of cancer death in the ...

Study Explores Which Patients Respond Best to Vectibix 04/19/2010
Previous studies have reported that colorectal cancers with mutations in a gene known as KRAS do not respond well to drugs such as Vectibix® (panitumumab). In an effort to expand these findings and further individualize colorectal cancer treatment, researchers evaluated several additional genes. The results were ...

Most Survivors of Lung and Colorectal Cancer Keep Their Jobs 04/14/2010
Among people diagnosed with nonmetastatic lung or colorectal cancer, the majority return to work, according to a study recently published in Journal of Clinical Oncology. Those who do leave the workforce tend to have worse prognoses and lower socioeconomic status. Cancer treatment affects everyone differently, and many ...

Lower Use of Diagnostic Testing May Explain Higher Colorectal Cancer Mortality in African Americans 04/06/2010
The higher incidence and mortality from colorectal cancer among African Americans compared with Whites may be due to differences in health care utilization rather than differences in susceptibility to cancer, according to a study published in the Journal of the National ...

Sandostatin Ineffective in Preventing Diarrhea in Anal and Rectal Cancer Patients Treated with Chemoradiotherapy 03/31/2010
Sandostatin® (ocreotide acetate) does not prevent diarrhea in patients with anal or rectal cancer treated with chemotherapy and radiation therapy. The results of this randomized, double-blind, placebo controlled trial were recently reported in the Journal of the National Cancer Institute.1 Diarrhea is a common side effect ...

Cost Versus Benefit Among Chemotherapy Drugs for Metastatic Colorectal Cancer 03/26/2010
New chemotherapy agents for metastatic colorectal cancer modestly improve survival time but come with substantial costs, according to the results of a study published in the Archives of Internal Medicine.[1] Metastatic colorectal cancer refers to cancer that has spread from the colon to distant sites in ...

Low Levels of Vitamin B6 May Increase Risk of Colorectal Cancer 03/23/2010
Individuals with low blood levels of an active form of vitamin B6 or low dietary intake of vitamin B6 may have an increased risk of developing colorectal cancer. These results, based on an analysis of several previously published studies, were published in the Journal of the ...

Preventive Treatment Reduces Skin Side Effects of Vectibix 02/16/2010
Among patients with metastatic colorectal cancer treated with the targeted therapy Vectibix® (panitumumab), preventive skin care reduces the occurrence of skin side effects. These results were published in the Journal of Clinical Oncology. Colorectal cancer remains the second leading cause of cancer-related death in the United ...

Vectibix Improves Outcome of Previously Treated Colorectal Cancer 01/27/2010
Among patients with previously treated, metastatic colorectal cancer, the addition of the targeted therapy Vectibix® (panitumumab) to chemotherapy delayed cancer progression. This benefit was only observed in patients whose tumors did not contain a mutation in the KRAS gene. These results were presented at the 2010 ...

Review Confirms Effectiveness of Avastin® plus Chemotherapy in Advanced Colorectal Cancer 01/20/2010
Among patients with advanced colorectal cancer, the addition of Avastin® (bevacizumab) to chemotherapy improves overall and progression-free survival but also increases side effects. These results were published in the Annals of Oncology. Colorectal cancer is the second leading cause of cancer death in the United States. Treatment of advanced colorectal cancer ...

Physical Activity Improves Survival of Men with Localized Colorectal Cancer 12/23/2009
Men who report the most physical activity after a diagnosis of non-metastatic colorectal cancer have a lower risk of death than men who report the least activity. These results were published in the Archives of Internal Medicine. There are over 10 million cancer survivors in the United States, and this number ...

Home Care Nursing Improves Symptom Management 12/04/2009
Among breast and colorectal cancer patients treated with the oral chemotherapy drug Xeloda® (capecitabine), symptom management was better among patients who received home care nursing than among patients who received standard care. These results were published in the Journal of Clinical Oncology. Xeloda is an oral chemotherapy drug that has been ...

Combination of Erbitux® and Chemotherapy Shows Promise Against Liver Metastases 12/02/2009
Among patients with liver metastases from colorectal cancer, the combination of Erbitux® (cetuximab) and chemotherapy may improve treatment response rates and increase the number of patients who become candidates for surgery. These results were published in Lancet Oncology. Colorectal cancer remains the second leading cause of cancer-related deaths in the United ...

Early Morning Colonoscopies Detect More Polyps 11/11/2009
Among patients undergoing colonoscopy at a Veteran’s Administration (VA) medical center, a greater number of polyps was detected among patients seen early in the morning than among patients seen later in the day. The reasons for this are uncertain, but it’s possible that the lower rate of polyp detection later ...

Excess Body Weight Linked with More Than 100,000 New Cancer Diagnoses Each Year in U.S. 11/09/2009
According to estimates from the American Institute for Cancer Research (AICR), excess body weight may be responsible for more than 100,000 new cancer diagnoses each year in the United States. Excess body weight is increasingly recognized as a risk factor not only for cancer development but also for worse outcomes after ...

Daily Aspirin Prevents Colorectal Cancer in Lynch Syndrome 10/05/2009
Daily aspirin may prevent the incidence of cancer in individuals who are genetically predisposed to hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch Syndrome, according to the results of a study presented September 21, 2009 at Europe’s largest cancer congress, ECCO 15-ESMO 34, in Berlin.[1] Hereditary nonpolyposis ...

First-line Vectibix Modestly Improves Colorectal Cancer Outcome 09/25/2009
Among patients with metastatic colorectal cancer, initial treatment with a combination of chemotherapy and Vectibix® (panitumumab) delays cancer progression by 1.6 months compared with chemotherapy alone. This benefit, which was reported at a major European cancer conference, only applied to patients whose tumors did not contain a mutation in the ...

Vectibix Delays Progression of Metastatic Colorectal Cancer 09/23/2009
Among patients with previously treated, metastatic colorectal cancer, the addition of the targeted therapy Vectibix® (panitumumab) to chemotherapy delayed cancer progression. This benefit was only observed in patients whose tumors did not contain a mutation in the KRAS gene. These results were presented at a major European cancer conference. Colorectal ...

Addition of Vectibix® to Second-line Chemotherapy Improves Progression-free Survival in Metastatic Colorectal Cancer 08/24/2009
Among patients with previously treated, metastatic colorectal cancer, the addition of the targeted therapy Vectibix® (panitumumab) to chemotherapy delayed cancer progression. This benefit was only observed in patients whose tumors did not contain a mutation in the KRAS gene. These results were made available in a press release from Amgen. Colorectal ...

Aspirin May Improve Survival in Colon Cancer 08/17/2009
Regular aspirin use after a colorectal cancer diagnosis may reduce the risk of dying from the disease, especially among tumors that overexpress the COX-2 enzyme, according to the results of a study published in the Journal of the American Medical Association.[1] Previous studies have shown that regular aspirin use reduces ...

CT Colonography May Be Appropriate Screening Test for Some High-risk Individuals 06/22/2009
CT Colonography May Be Appropriate Screening Test for Some High-risk Individuals Among people at increased risk of colorectal cancer, computed tomographic (CT) colonography correctly classified 85% of the people with advanced adenomas or cancer and 88% of the people without advanced adenomas or cancer. These results were published in the Journal ...

Age and Illness Increase Colonoscopy Risks 06/18/2009
Age and Illness Increase Colonoscopy Risks Although the risk of complications from colonoscopy is low, risk increases among the very elderly and among those with certain chronic health conditions. These results were published in the Annals of Internal Medicine. Colon cancer is the second leading cause of cancer death in the United ...

Preemptive Skin Treatment Reduces Skin Toxicity Associated with Vectibix® in Patients with Metastatic Colorectal Cancer 06/09/2009
Preemptive Skin Treatment Reduces Skin Toxicity Associated with Vectibix® in Patients with Metastatic Colorectal Cancer Early skin treatment that is initiated prior to the start of EGFR treatment with Vectibix® (panitumumab) reduces the incidence and severity of skin toxicity and improves quality of life in patients with metastatic colorectal cancer, according ...

Surgery Unnecessary for Most Patients with Metastatic Colorectal Cancer 06/02/2009
Surgery Unnecessary for Most Patients with Metastatic Colorectal Cancer Patients with newly diagnosed metastatic colorectal cancer do not need to undergo surgical removal of their tumor unless the tumor is causing complications, according to the results of a study presented at the 2009 Annual Meeting of the American Society of Clinical ...

Colorectal Cancer Screening Reduces Mortality 02/23/2009
The implementation of colorectal cancer screening appears to reduce mortality from the disease, as evidenced by the disparity between mortality rates among regions that implemented screening at different times. The results of this study were published in the Journal of the National Cancer Institute.

Combination of Avastin® and Erbitux® Worsens Colorectal Cancer Outcomes 02/13/2009
Among patients with previously untreated, metastatic colorectal cancer, the addition of Erbitux® (cetuximab) to Avastin® (bevacizumab) and chemotherapy resulted in shorter progression-free survival and worse quality of life. These results were published in the New England Journal of Medicine.Colorectal cancer remains the second leading cause of cancer deaths in the United ...

Aspirin and/or Resistant Starch Have No Effect on Colorectal Cancer Incidence Among People with Lynch Syndrome 02/12/2009
The use of aspirin and/or resistant starch has no effect on the incidence of colon cancer among individuals with Lynch Syndrome, according to the results of a study published in the New England Journal of Medicine.[1]Lynch Syndrome, also known as hereditary nonpolyposis colorectal cancer ...

Avastin® plus Fluorouracil-based Chemotherapy Effective in Elderly with Metastatic Colorectal Cancer 02/11/2009
Patients aged 65 or older with metastatic colorectal cancer benefit as much from Avastin® (bevacizumab) plus fluorouracil-based chemotherapy as their younger counterparts, according to the results of a study published in the Journal of Clinical Oncology.[1]Colorectal cancer remains the second leading cause of ...

The Evolving Role of EGFR Inhibitors in Colorectal Cancer—A Report from ASCO 2008 01/23/2009
Results from the 2008 annual meeting of the American Society of Clinical Oncology (ASCO), held May 30–June 2 in Chicago, Illinois, revealed significant steps towards the improvement of outcomes for patients with varying types of cancers. As seen during the past few years, attention has turned towards individualizing patient ...

Postmenopausal Hormones Reduce the Risk of Colorectal Cancer 01/22/2009
According to the results of a study published in Cancer Epidemiology, Biomarkers, & Prevention, use of postmenopausal hormones reduces the risk of colorectal cancer.Postmenopausal hormone therapy with either estrogen alone or estrogen plus progestin effectively manages several common menopausal symptoms. However, large clinical trials conducted as part of the ...

Colonoscopy Fails to Identify Many Colorectal Cancers 01/06/2009
Colonoscopy, a standard screening method for colorectal cancer, misses the majority of cancers on the right side of the colon and about one-third of cancers on the left side of the colon, according to the results of a study published in the Annals of Internal Medicine.

CT Colonography Accurately Detects Large Colon Cancers 09/18/2008
The use of computed tomographic colonography (CTC) accurately detects 90% of large colon cancers among patients who do not exhibit any symptoms of colon cancer. These results were recently published in the New England Journal of Medicine.Colon cancer is the third most common and second most deadly cancer in ...

A-Type Lamins Associated with Aggressive Colorectal Cancer 08/27/2008
Proteins called A-type lamins appear to indicate the presence of aggressive disease in patients with colorectal cancer. A-type lamins may also play a role in determining treatment options among these patients. These results were recently published in the journal PLoS ONE.Colorectal cancer is the second leading cause of cancer-related ...

Early Skin Treatment Reduces Skin Reactions in Colorectal Cancer Patients Treated with Vectibix® 08/22/2008
Among patients with colorectal cancer, skin treatment beginning on the day prior to therapy with Vectibix® (panitumumab) significantly reduces skin side effects associated with Vectibix compared with skin treatment after side effects occur. These results were presented at the 10th World Congress on Gastrointestinal Cancer held in Spain in ...

More Fruits and Veggies, Less Meat Reduces Colorectal Cancer 08/14/2008
Individuals who consume a diet that is rich in vegetables, fruits, whole grains, and healthy oils, contains sufficient dietary calcium and vitamin D, and is low in solid fats, added sugar, and red meats have a significantly reduced risk of developing colorectal cancer. These results were recently published in the American Journal ...

Low Risk of Perforation During Colonoscopy Screening for Colorectal Cancer 08/07/2008
Perforation (a tear through the colon wall caused by a colonoscopy procedure) occurs in less than one in 1,000 patients undergoing a colonoscopy. These results were recently published in the Archives of Surgery.A colonoscopy is a procedure that involves the insertion of a lighted tube through the large intestine ...

Higher Vitamin D Levels Result in Better Survival Among Colorectal Cancer Patients 07/15/2008
Among patients diagnosed with colorectal cancer, those with higher levels of vitamin D in their blood prior to diagnosis have an improved survival compared with those with lower levels. These results were recently published in the Journal of Clinical Oncology.Vitamin D is a fat-soluble vitamin that comes from dietary ...

Physicians with More Training Perform More Effective Colonoscopies 04/30/2008
A recent trial conducted at 15 different medical centers in Korea indicates that a physician must perform at least 150 colonoscopies to be considered competent at the procedure. Details of the study were recently published in the journal Gastrointestinal Endoscopy.Colonoscopy is a procedure in which a colonoscope is passed ...

Celebrex® Reduces Colon Adenomas 04/17/2008
The COX2-inhibitor Celebrex® (celecoxib) reduces the rate of colon adenomas at five years and appears safe, even among patients with cardiovascular disease. These results were recently presented as a late-breaking abstract at the 2008 annual meeting of the American Association for Cancer Research.Adenomas are abnormal growths that often arise ...

Drug Combination Decreases Recurrence Rate of Colon Polyps 04/15/2008
The combination of the difluoromethylornithine (DFMO) and sulindac reduces the rate of colon adenomas (growths or polyps) by up to 95% among patients who have had prior colon polyps. These results were presented as a late-breaking abstract at the 2008 annual meeting of the American Association for Cancer Research.Adenomas ...

Combination of Erbitux® and Camptosar® Improves Outcome in Metastatic Colorectal Cancer 04/14/2008
The combination of Erbitux® (cetuximab) and Camptosar® (irinotecan) may be more effective than Camptosar alone for the treatment of metastatic colorectal cancer that is positive for the epidermal growth factor receptor. This study was recently published online in the Journal of Clinical Oncology.Colorectal cancer is the ...

Testing for Specific Protein May Identify Colorectal Patients Who Will Benefit from Erbitux® 04/07/2008
Researchers have identified a test to predict which patients with colorectal cancer would likely respond to treatment with Erbitux® (cetuximab). Details of the study were recently published in the Annals of Oncology.Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Colorectal cancer involves the ...

March Is National Rectal Cancer Awareness Month 03/20/2008
As the month of March brings rectal cancer into focus, it's a great time to increase public understanding of the disease, including its prevalence, approaches to screening and prevention, treatment options, and resources that offer updated colorectal cancer information throughout the year.According to estimates from the American Cancer Society, ...

Hemoglobin Level Among Factors that May Predict Outcome in Rectal Cancer 03/17/2008
Researchers in the United States have recently published results indicating that certain prognostic factors may predict outcome for patients undergoing radiation for locally recurrent rectal cancer. These results were recently published in the International Journal of Radiation Oncology Biology and Physics.The rectum is part of the digestive system. It ...

Common Colorectal Polyps More Likely to Be Malignant 03/12/2008
A certain common colorectal polyp is much more likely to be malignant than previously thought. Results from this study, conducted at the Veterans Affairs Palo Alto Health Care System, were recently published in the Journal of the American Medical Association.Colorectal polyps are growths that occur in the lining of ...

Tobacco Use Associated with Earlier Onset of Colorectal Cancer 02/22/2008
A recent study finds that individuals with a history of long-term, heavy tobacco use were diagnosed with colorectal cancer at a significantly younger age than individuals who had never smoked. These findings were recently published in the Journal of Cancer Research and Clinical Oncology.A current focus in cancer research ...

Elderly Rectal Cancer Patients May Benefit from Combined Chemotherapy and Radiation 02/14/2008
Elderly patients diagnosed with rectal cancer may benefit from combined treatment with chemotherapy and radiation. These results were recently published in the journal Cancer.The rectum is part of the digestive system. It makes up the final six inches of the large intestine. Cancer of the colon or rectum is ...

Physicians Influence Rates of Colorectal Screening 02/13/2008
Healthcare providers can greatly influence the rates at which patients undergo screening for colorectal cancer. These results were recently published in the journal Cancer.Colorectal cancer remains the second leading cause of cancer-related deaths in the United States. When detected and treated early, prior to spread, cure rates for colorectal ...

Chemotherapy for Stage II Colorectal Cancer Improves Survival 01/16/2008
According to results recently published in Lancet Oncology, chemotherapy for Stage II colorectal cancer appears to provide a modest improvement in survival.Colorectal cancer remains the second leading cause of cancer-related deaths in the United States. Stage II (or B) colorectal cancer refers to cancer that has penetrated the wall ...

Meat Linked to Various Cancers 12/13/2007
According to an article recently published in the Public Library of Science Medicine journal, increased consumption of beef, pork, lamb, or processed meats such as bacon, sausage, or ham significantly increases the risk of developing several types of cancers.Cancer is diagnosed in more than 10 million people around the ...

Study Explores Postmenopausal Hormone Use, Weight, and Risk of Colorectal Cancer in Women 12/05/2007
In a study conducted in Germany and published in the British Journal of Cancer, use of postmenopausal hormones decreased the risk of colorectal cancer in women. In contrast to several previous studies, however, being overweight increased the risk of colorectal cancer only among women who had never used postmenopausal ...

Smoking Increases Risk of Rectal Cancer 11/28/2007
According to results recently published in the Journal of the National Cancer Institute, smoking increases the risk of developing rectal cancer.An active area of cancer research focuses on the association between environmental variables and risk of developing specific cancers.  Results from studies have demonstrated definite links between diet, exercise, ...

Erbitux® Improves Survival in Colorectal Cancer 11/16/2007
According to an article recently published in the New England Journal of Medicine, the targeted agent Erbitux® (cetuximab) improves overall and progression-free survival while maintaining quality of life for patients with recurrent colorectal cancer.Colorectal cancer is the second leading cause of cancer-related deaths in the United States.  Advanced colorectal ...

CT Colonography Detects Abnormalities Outside the Colon 11/13/2007
Researchers from the UK have reported that CT colonography (also known as “virtual colonoscopy”) may play an important role in evaluating older patients with lower gastrointestinal symptoms because CT colonography can detect abnormalities outside of the colon. These results were published in the American Journal of Roentgenology.Colorectal cancer is ...

Vitamin D May Reduce Colorectal Cancer Mortality 11/07/2007
According to the results of a study published in the Journal of the National Cancer Institute, higher circulating vitamin D levels may reduce the risk of death from colorectal cancer.  Vitamin D is a fat-soluble vitamin that comes from dietary supplements, foods such as fortified milk and cereal, certain ...

Erbitux®/Avastin®/Camptosar® Appears Effective in Colorectal Cancer Patients Not Responding to Camptosar Alone 10/15/2007
According to an article recently published in the Journal of Clinical Oncology, the addition of the targeted agent Avastin® (bevacizumab) to treatment including the targeted agent Erbitux® (cetuximab), with or without the chemotherapy agent Camptosar® (irinotecan), appears effective for patients with advanced colorectal cancer who do not respond to ...

Patient Communication and Expectations: ASCO GI 2007 10/15/2007
The 2007 Gastrointestinal Cancers Symposium held January 19-21 in Orlando, Florida, was the fourth annual multidisciplinary symposium on gastrointestinal (GI) cancers, bringing together leading experts to present and discuss new research on prevention, screening, and treatment. Dr. Neil Love and colleagues presented an abstract titled, “How well do we ...

Developments in the Treatment of Colorectal Cancer: A Report from ASCO GI 2007 10/15/2007
IntroductionThe 2007 Gastrointestinal Cancers Symposium, held January 19-21 in Orlando, Florida, was co-sponsored by the American Society of Clinical Oncology (ASCO), the American Gastroenterological Association (AGA), the American Society for Therapeutic Radiology and Oncology (ASTRO), and the Society of Surgical Oncology (SSO).  This was the fourth annual multidisciplinary ...

Cure at Ten-year Survival Following Surgery to Remove Colon Cancer Spread to Liver 10/12/2007
According to an article recently published in the Journal of Clinical Oncology, patients surviving 10 years following the surgical removal of cancer that has spread from the colon to the liver can consider themselves cured. Furthermore, the authors state: “In well-selected patients, there is at least a one in ...

Advances in the Treatment of Metastatic Colorectal Cancer: ASCO 2007 10/12/2007
IntroductionThe past decade has been an era of rapid proliferation of new drugs and regimens for metastatic colorectal cancer (mCRC).  With seven active drugs now available including four chemotherapeutic agents: 5-fluorouracil, capecitabine, irinotecan, and oxaliplatin, and three targeted agents: bevacizumab, cetuximab, and panitumumab, there are many possibilities for ...

Virtual Colonoscopy Suggested as Initial Screening for Colorectal Cancer 10/04/2007
According to an article recently published in the New England Journal of Medicine, virtual colonoscopy, also referred to as computed tomographic colonography (CTC), is an effective initial screening measure for the detection of colorectal cancer.Colorectal cancer is the second leading cause of cancer-related deaths in the United States. If ...

Fecal Immunochemical Test Detects High Percentage of Colon Cancers 09/28/2007
According to the results of a study published in the Journal of the National Cancer Institute, use of a newer type of fecal occult blood test known as a fecal immunochemical test detected a high percentage of left-sided colorectal cancers (cancers that develop in the last part of the ...

No Clear Link between Fruit and Vegetable Intake and Colon Cancer Risk 09/27/2007
According to the results of a study published in the Journal of the National Cancer Institute, higher intake of fruits and vegetables does not appear to reduce the risk of colon cancer.Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. The disease develops in the ...

Higher Rates of Colorectal Cancer in Patients with Coronary Artery Disease 09/26/2007
According to the results of a study conducted in Hong Kong, patients with coronary artery disease have a higher rate of colorectal polyps and colorectal cancer than individuals without coronary artery disease. These results were published in the Journal of the American Medical Association.Colorectal cancer is the second leading ...

Gene Linked with Response to Vectibix™ in Colorectal Cancer 09/26/2007
In a study of patients with previously-treated metastatic colorectal cancer, treatment with VectibixTM (panitumumab) benefited only those patients with tumors that lacked mutations in a gene known as KRAS. These results were presented at the European Cancer Conference (ECCO 14).Colorectal cancer remains the second leading cause of cancer-related deaths ...

Avastin® Increases Risk of Blood Clots in Arteries 09/04/2007
According to a combined analysis of five clinical trials, treatment of metastatic colorectal cancer, breast cancer, or non–small lung cancer with a combination of Avastin and chemotherapy results in a higher risk of arterial blood clots than treatment with chemotherapy alone. These results were published in the Journal of ...

Diet High in Choline Linked with Increased Risk of Colorectal Polyps 08/31/2007
According to the results of a study published in the Journal of the National Cancer Institute, high intake of choline—a nutrient found in foods such as red meat, eggs, poultry, and dairy products—may be linked with an increased risk of colorectal polyps.Colorectal cancer is the second leading cause of ...

Rate of Colorectal Cancer Screening with Colonoscopy in First-degree Relatives Needs Improvement 08/30/2007
According to an article recently published in Annals of Oncology, screening colonoscopy rates for individuals with a first-degree relative diagnosed with colorectal cancer remain suboptimal. It is recommended that patients diagnosed with colorectal cancer are made aware that their first-degree relatives have an increased risk of developing the disease; ...

Continuous Pain Medicine at Wound Site Shortens Recovery Time for Colorectal Cancer Surgery 08/27/2007
According to an article recently published in Anesthesiology, continuous administration of anesthesia at the site of the surgical wound significantly improves pain and accelerates recovery for patients with colorectal cancer.The surgical removal of cancer and surrounding tissue is a standard part of treatment in colorectal cancer, particularly if the ...

Addition of Vectibix™ to Avastin® plus Chemotherapy Does Not Improve Outcomes for Metastatic Colorectal Cancer 08/24/2007
According to results presented at the 9th World Congress on Gastrointestinal Cancer, the addition of Vectibix™ (panitumumab) to Avastin® (bevacizumab) and the chemotherapy regimens FOLFOX or FOLFIRI does not improve outcomes for patients with metastatic colorectal cancer.Colorectal cancer remains the second leading cause of cancer-related deaths in the United ...

Addition of Avastin® to FOLFOX Produces High Activity in Metastatic Colorectal Cancer 08/23/2007
According to an article published in BMC Cancer, the addition of the targeted agent Avastin® (bevacizumab) to the chemotherapy regimen FOLFOX provides impressive results and is well tolerated as treatment for metastatic colorectal cancer.Colorectal cancer remains the second leading cause of cancer-related deaths in the United States. Metastatic colorectal ...

Reintroduction of Eloxatin® Improves Survival in Colorectal Cancer Patients 08/22/2007
According to an article recently published in the Journal of Clinical Oncology, reintroduction of Eloxatin® (oxapliatin)-based chemotherapy improves survival for patients with advanced colorectal cancer.Colorectal cancer remains the second leading cause of cancer-related deaths in the United States. Advanced colorectal cancer refers to cancer that has spread from its ...

Vectibix™ Effective as Single Agent for Colorectal Cancer 08/08/2007
According to an early online publication in the journal Cancer, the targeted agent Vectibix™ (panitumumab) has anticancer activity when used as a single agent among patients who have received prior therapy for colorectal cancer.Colorectal cancer remains the second leading cause of cancer-related deaths in the United States. Patients who ...

Updates in the Management of Gastrointestinal Cancers: A Report from the 9th World Congress on Gastrointestinal Cancer 08/07/2007
 Introduction The 9th Annual World Congress on Gastrointestinal Cancer was held in Barcelona, Spain, June 28 through July 1, 2007 in association with the European Society of Medical Oncology. This meeting continues to grow and is a forum for the review of data recently presented at ...

Patient Time Requirements for Screening Colonoscopy Defined 07/31/2007
According to an early online article published by the American Journal of Gastroeneterology, time requirements of a patient for undergoing screening colonoscopy have been defined. It is important that patients understand this time commitment prior to scheduling a colonoscopy.Colorectal cancer is the second leading cause of cancer-related deaths in ...

Smokers May Benefit Less from Camptosar® than Nonsmokers in Colorectal Cancer 07/30/2007
According to an article recently published in the Journal of Clinical Oncology, smoking may reduce the body's ability to effectively metabolize the chemotherapy agent Camptosar® (irinotecan) in the treatment of colorectal cancer. It appears that smoking may reduce the exposure of the drug's cancer killing effects to cancer cells.It is ...

Recurrence Rates for Liver Metastases Reduced when Neoadjuvant and Adjuvant Chemotherapy are Used with Surgery 07/30/2007
According to results from a late-breaking session at the 2007 annual meeting of the American Society of Clinical Oncology (ASCO), patients with colorectal cancer whose cancer has spread to the liver (liver metastases) have improved survival without cancer recurrences when they receive chemotherapy prior to and following surgery, compared ...

Smoking Associated with Increased Risk of Colorectal Cancer 07/18/2007
According to an article recently published in Cancer Epidemiology, Biomarkers and Prevention, smoking increases the risk of developing colorectal cancer.A current focus in cancer research is the study of environmental factors and risks of developing certain types of cancer. Smoking tobacco products has been implicated in an increased risk ...

Sequential Chemotherapy as Effective as Concurrent Chemotherapy in Advanced Colorectal Cancer 07/16/2007
According to results recently published in The Lancet, sequential administration of chemotherapy appears just as effective as concurrent administration among patients with advanced colorectal cancer.Advanced colorectal cancer refers to cancer that has spread from its site of origin to more distant sites in the body. Typically, chemotherapy is used ...

Adequate Removal of Lymph Nodes Necessary for Accurate Staging and Optimal Survival in Colorectal Cancer 06/26/2007
According to results recently published in the Journal of Clinical Oncology, adequate removal of lymph nodes affects accurate staging of colorectal cancer. Furthermore, patients with colorectal cancer who do not undergo adequate removal of lymph nodes have a reduced survival.Colorectal cancer is one of the leading causes of cancer-related deaths in ...

Aspirin Protects Against Subset of Colorectal Cancers 05/25/2007
According to the results of a study published in the New England Journal of Medicine, regular, long-term aspirin use reduces the risk of colorectal cancers that overexpress the COX-2 enzyme.Colorectal cancer is the second leading cause of cancer-related deaths in the United States, highlighting the importance of finding effective ...

Low Levels of Magnesium Associated with EGFR Antibodies in Colorectal Cancer 05/03/2007
According to an article recently published in the Lancet Oncology, low levels of magnesium in the blood occur in 97% of patients treated with epidermal growth factor receptor (EGFR)-targeting antibodies for colorectal cancer.The EGFR pathway is involved in cellular growth and replication and is often mutated or overexpressed among ...

Erbitux® Improves Outcomes in Advanced Colorectal Cancer 04/26/2007
Two studies presented at the 2007 annual meeting of the American Association for Cancer Research (AACR) indicate that Erbitux® (cetuximab) improves treatment outcomes in patients with previously-treated metastatic colorectal cancer.Colorectal cancer remains the second leading cause of cancer-related death in the United States. Metastatic colorectal cancer refers to cancer ...

Room for Improvement in Screening of Patients with Family History of Colorectal Cancer 04/03/2007
According to the results of a study published in the Journal of General Internal Medicine, many individuals with a strong family history of colorectal cancer are not aware that they should consider starting colorectal cancer screening at a younger age than average-risk individuals.Colorectal cancer is the second leading cause ...

Radioactive Microspheres plus Chemotherapy Provide Great Anticancer Activity in Advanced Colorectal Cancer 03/21/2007
According to an article recently published in the Journal of Clinical Oncology, microspheres that contain a radioactive substance along with the chemotherapy regimen referred to as FOLFOX4 provide substantial anticancer activity among patients with colorectal cancer that has spread to the liver.Colorectal cancer is the second leading cause of ...

Aspirin and NSAIDS Not Recommended for Colorectal Cancer Prevention 03/20/2007
According to a report issued by the U.S. Preventive Services Task Force, the use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDS) for the prevention of colorectal cancer is not recommended for individuals at average risk of colorectal cancer; the harms appear to outweigh the benefits.Colorectal cancer is the ...

Immunochemical FOBT Aids in Detection of Colorectal Cancer and Colorectal Polyps 03/08/2007
According to the results of a study published in the Annals of Internal Medicine, the newer type of fecal occult blood test (FOBT) known as an immunochemical FOBT performs better than older approaches to FOBT in the detection of colorectal cancer and colorectal polyps.Colorectal cancer is the second leading ...

Variables Affect Rate of Missed Cancers on Colonoscopy 02/26/2007
According to an article published in the journal Gastroenterology, colonoscopies performed in an office or performed by an internist or family physician carry a higher risk of missing colorectal cancers compared to colonoscopies performed in a hospital setting or performed by a gastroenterologist.Colorectal cancer remains the second leading cause ...

Disparities Persist in Colorectal Cancer Screening 02/20/2007
According to the results of a study published in the Archives of Internal Medicine, non-White Medicare beneficiaries are roughly half as likely as White Medicare beneficiaries to be screened for colorectal cancer.Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. The disease develops in the ...

Celebrex® Does Not Increase Effectiveness of FOLFOX 02/05/2007
Among patients treated with the FOLFOX7 chemotherapy regimen for metastatic colorectal cancer, the addition of Celebrex® (celecoxib) did not further improve outcomes. These results were published in Annals of Oncology.Colorectal cancer is the second leading cause of cancer-related deaths in the United States. The disease develops in the large ...

XELOX and FOLFOX Produce Comparable Survival in Advanced Colorectal Cancer 01/23/2007
According to results from a press release from Roche, as well as results presented at the 2007 annual meeting of the American Society of Clinical Oncology Gastrointestinal Symposium,  the chemotherapy combination referred to as XELOX provides the same survival as FOLFOX as initial therapy for metastatic colorectal cancer. (XELOX, ...

Effect of Calcium Supplementation on Adenoma Recurrence Persists for at Least Five Years After Treatment 01/18/2007
According to the results of a study published in the Journal of the National Cancer Institute, a protective effect of calcium supplementation on risk of colorectal adenoma recurrence persisted for up to five years after the end of the study.Colorectal cancer is the second leading cause of cancer-related deaths ...

Estrogen Use May Increase Survival in Patients with Colorectal Cancer 01/12/2007
According to an article recently published in the Journal of Clinical Oncology, women who have been diagnosed with colorectal cancer may have a decreased risk of death if they have used estrogen for hormone replacement therapy, particularly if estrogen was used within five years of diagnosis.As women reach menopause ...

Addition of Erbitux® to FOLFIRI Improves Progression-free Survival in Metastatic Colorectal Cancer 01/10/2007
According to a press release by ImClone Systems, the addition of the targeted agent Erbitux® (cetuximab) to the chemotherapy regimen referred to as FOLFIRI improves progression-free survival compared to FOLFIRI alone in the treatment of metastatic colorectal cancer.Colorectal cancer remains the second leading cause of cancer-related deaths in the ...

Statins Not Protective Against Colorectal Cancer 01/04/2007
According to the results of a study published in the Journal of the National Cancer Institute, use of cholesterol-lowering drugs known as statins does not appear to reduce the risk of developing colorectal cancer.Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. The disease develops ...

Erbitux® Combinations Evaluated in Rectal and Esophageal Cancer 01/02/2007
Two recent studies presented at the 2006 meeting of the American Society for Therapeutic Radiation and Oncology (ASTRO) suggest that Erbitux® (cetuximab) can be safely added to combination chemotherapy regimens for rectal and esophageal cancer.Cancer of the esophagus (the tube leading to the stomach) is relatively uncommon, but is ...

Rushed Colonoscopies May Miss Polyps 12/21/2006
According to the results of a study published in the New England Journal of Medicine, physicians who withdraw the colonoscope more quickly during routine screening colonoscopy detect fewer colorectal polyps than physicians who withdraw the colonoscope more slowly.Colorectal cancer is the second leading cause of cancer-related deaths in the ...

Delay in Chemotherapy Associated with Worse Outcomes for Elderly with Colorectal Cancer 11/27/2006
According to an article recently published in the journal Cancer, a delay in chemotherapy longer than three months following surgery is associated with worse outcomes for elderly patients with colorectal cancer. Fortunately, these delays are not common.Colorectal cancer is the second leading cause of cancer-related deaths in the United ...

Colonoscopy Finds More Advanced Cancers in Men than Women 11/03/2006
According to an article recently published in the New England Journal of Medicine, screening colonoscopy tends to find advanced colorectal cancer at higher rates in men than in women. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. If colorectal cancer is detected and ...

Anemia Influences Outcomes in Patients with Rectal Cancer 10/30/2006
According to a study published in the Annals of Oncology, anemia results in worse cancer-free survival among rectal cancer patients undergoing preoperative (neoadjuvant) chemotherapy and/or radiation therapy. The rectum is the last portion of the large intestine. Standard treatment for rectal cancer often includes the surgical removal of as much ...

Red Wine May Help Reduce Colorectal Cancer 10/30/2006
According to results recently presented at the 2006 annual meeting of the American College of Gastroenterology, three or more glasses of red wine per week may reduce the risk of developing colorectal cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Due to its ...

Amgen Offers Financial Assistance for Vectibix™ 09/29/2006
Amgen has announced that it has initiated a program, referred to as the Oncology Assistance (AOA) program, to provide financial assistance for patients using Vectibix™ (panitumumab). Vectibix is a monoclonal antibody that has recently been approved by the Food and Drug Administration (FDA) for the treatment of metastatic colorectal cancer ...

Vectibix™ Approved for Colorectal Cancer 09/28/2006
The United States Food and Drug Administration (FDA) has approved the monoclonal antibody Vectibix™ (panitumumab) for the treatment of advanced colorectal cancer among patients who received two prior therapeutic regimens. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. Metastatic colorectal refers to cancer that has ...

Researchers Continue to Improve Identification of Lynch Syndrome 09/27/2006
Two new tools have been developed to predict an individual's risk of carrying a gene mutation linked with hereditary colorectal cancer. Use of these tools may guide decisions about genetic testing. Descriptions of these tools were published in the Journal of the American Medical Association. Lynch Syndrome, also known as ...

MRI Can Help Predict if Rectal Cancer May Be Surgically Removed 09/22/2006
According to an article recently published in the British Medical Journal, magnetic resonance imaging (MRI) can help determine if cancer can be completely removed by surgery among patients diagnosed with early rectal cancer. Results from an MRI can indicate which patients may benefit from treatment prior to surgery to ...

HNPCC Families Show Abnormal Reflection of Light from Tissues in Mouth 09/22/2006
According to the results of a study conducted in Italy, evaluation of how light reflects off of tissue in the mouth may help identify patients at high risk of a specific type of hereditary colorectal cancer. These results were published in the journal Gut. Lynch Syndrome, also known as hereditary ...

Chemotherapy Before Surgery Does Not Improve Survival in Rectal Cancer 09/15/2006
According to an article recently published in the New England Journal of Medicine, chemotherapy survival rates are similar among patients with rectal cancer whether chemotherapy is given before or after surgery. The rectum is the last portion of the large intestine. Standard treatment for rectal cancer often includes the surgical ...

Patients Prefer Conventional Colonoscopy 09/05/2006
According to a study published in the American Journal of Medicine, patients prefer conventional colonoscopy over virtual colonoscopy or barium enema as a screening test for colorectal cancer. Colorectal cancer is the second-leading cause of cancer-related deaths in the U.S. Screening tests for colorectal cancer include fecal occult blood test ...

Further Evidence of Association Between Diabetes and Increased Risk of Colorectal Cancer 08/31/2006
According to an article recently published in the American Journal of Gastroenterology, type 2 diabetes increases the risk of developing colorectal cancer, particularly among men and smokers. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. If detected and treated early, cure rates for colorectal cancer ...

Celebrex® Reduces Pre-cancerous Colorectal Tumors but Increases Cardiovascular Risks 08/31/2006
According to two articles recently published in the New England Journal of Medicine, the cyclooxygenases 2 (COX-2) inhibitor Celebrex® (celecoxib) reduces the risk of pre-cancerous colorectal tumors (adenomas) among patients with previously diagnosed colorectal adenomas. However, the use of Celebrex is associated with an increased risk in cardiovascular side effects. Colorectal cancer ...

Changes in CEA Level After Surgery Linked to Outcomes in Rectal Cancer 08/25/2006
According to an article recently published in the Archives of Surgical Oncology, changes in carcinoembryonic antigen (CEA) levels following surgery, as compared to before surgery, are associated with survival among patients with Stage III rectal cancer. The rectum is the last portion of the large intestine. Standard treatment for rectal ...

CEA and Albumin Levels Associated with Survival in Colorectal Cancer 08/24/2006
According to an article recently published in the Journal of Clinical Gastroenterology, levels of the carcinoembryonic antigen (CEA) and albumin (ALB) are associated with survival among patients with early colorectal cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Early colorectal cancer refers to ...

Dietary Supplements Show Promise in Patients with Familial Adenomatous Polyposis 08/10/2006
Dietary supplementation with curcumin and quercetin may reduce the number and size of polyps in individuals with familial adenomatous polyposis who have undergone surgical removal of the colon. These results were published in the journal Clinical Gastroenterology and Hepatology. Adenomatous polyps are non-cancerous growths in the colon or rectum that ...

Chronomodulated Therapy for Colorectal Cancer Produces Promising Results in Men 08/04/2006
Among patients with metastatic colorectal cancer, administration of the chemotherapy drugs Eloxatin® (oxaliplatin), 5-fluorouracil, and leucovorin on a schedule that is adjusted to circadian rhythms (chronomodulated) appears to improve outcomes in men but not in women. These results were published in the Journal of Clinical Oncology. Colorectal cancer remains the ...

Scans plus Tumor Markers Detect Recurrences Earlier than Either Alone in Colorectal Cancer Patients 07/27/2006
According to an article recently published in the British Journal of Cancer, levels of tumor markers plus results from computed tomography (CT) scans predicted cancer recurrences earlier than either method alone among patients with colorectal cancer who had liver metastasis that had been surgically removed. The liver is a very ...

Virtual Colonoscopy Not Ready for Routine Screening for Colorectal Cancer 07/11/2006
According to results recently published in the American Journal of Gastroenterology, the American College of Gastroenterology (ACG) Action Plan on Colorectal Cancer Prevention has determined that computed tomography-colonography (CTC or virtual colonoscopy) is not ready for approval as an “effective and cost-effective strategy for colorectal cancer prevention.” Colorectal cancer is ...

Xaliproden Reduces Severity of Neuropathy Associated with Eloxatin® in Colorectal Cancer 06/21/2006
According to results presented at the 42nd annual meeting of the American Society of Clinical Oncology (ASCO), the agent xaliproden, still in clinical trials, appears to reduce the severity of peripheral neuropathy, a common side effect associated with the use of the chemotherapy agent Eloxatin® (oxaliplatin) in patients with ...

Addition of Erbitux® to XELOX Reduces Cancer Progression as First-line Therapy in Metastatic Colorectal Cancer 06/14/2006
According to results presented at the 42nd annual meeting of the American Society of Clinical Oncology (ASCO), the addition of the targeted agent Erbitux® (cetuximab) to the chemotherapy regimen referred to as XELOX significantly improves anticancer responses and reduces cancer progression compared to XELOX alone when used as initial ...

Panitumumab Targeted Therapy Provides Anticancer Activity in Patients with Advanced Colorectal Cancer 06/14/2006
According to results presented at the 42nd annual meeting of the American Society of Clinical Oncology (ASCO), the targeted agent panitumumab provides high anticancer responses in patients with advanced colorectal cancer that has stopped responding to standard therapies.Colorectal cancer is the second leading cause of cancer-related deaths in the ...

Confirmation that Erbitux® Provides Benefit in Metastatic Colorectal Cancer when Camptosar® Is Not Effective 06/06/2006
Researchers from Germany reported that the combination of Erbitux® (cetuximab) and Camptosar® (irinotecan) provides meaningful benefit in the treatment of patients with metastatic colorectal cancer that has not responded to prior Camptosar-based therapies. These results were presented at the 42nd annual meeting of the American Society of Clinical Oncology ...

Follow-Up Screening for Colorectal Cancer Inadequate 06/02/2006
According to an early online publication of Diseases of the Colon and Rectum, patient compliance with follow-up screening for colorectal cancer is inadequate following a positive fecal occult blood test (FOBT). Colorectal cancer remains the second leading cause of cancer-related deaths in the U.S. Early detection through screening for colorectal ...

Heart Disease and Diabetes Increase Risk of Colorectal Cancer 05/24/2006
According to results presented at the 2006 Digestive Disease Week meeting, individuals who are diabetic or those with coronary artery disease have an increased risk of developing colorectal cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. If detected and treated early, cure rates for ...

Decreased Risk of Colorectal Cancer Persists For More Than 10 Years after Negative Colonoscopy 05/24/2006
According to the results of a study published in the Journal of the American Medical Association, the decreased risk of colorectal cancer in individuals who have had a negative screening colonoscopy persists for more than 10 years after the colonoscopy. Colorectal cancer is the second leading cause of cancer-related deaths ...

Very Elderly May Derive Less Benefit from Colonoscopy 05/24/2006
According to the results of a study published in the Journal of the American Medical Association, the increase in life expectancy that results from screening colonoscopy is smaller for very elderly patients than for younger patients. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. The ...

Marker Helps Predict Response to 5-FU Chemotherapy in Early Colorectal Cancer 05/12/2006
According to an article recently published in the journal Gut, a molecular marker referred to as mismatch repair (MMR) deficiency may help to predict which patients will respond to chemotherapy including 5-fluorouracil (5-FU) for treatment of early colorectal cancer. Colorectal cancer is the second leading cause of cancer-related deaths in ...

High Fruit and Veggie Intake Reduces Development of Colorectal Adenomas in Women 05/11/2006
According to an article recently published in Cancer Research, high consumption of fruit and vegetables significantly reduces the incidence of colorectal polyps among women. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. Due to its prevalence, extensive research is aimed at uncovering variables that may ...

Study Supports Five-Year Interval for Screening with Flexible Sigmoidoscopy 05/09/2006
According to a study published in the American Journal of Gastroenterology, colorectal cancer screening with flexible sigmoidoscopy every five years produces similar results to screening with flexible sigmoidoscopy every three years. This suggests that a five-year interval is appropriate for screening with flexible sigmoidoscopy. Colorectal cancer is the second leading ...

Ulcerative Colitis Linked with Worse Colorectal Cancer Prognosis 05/05/2006
According to the results of a study conducted in Denmark, colorectal cancer patients with ulcerative colitis have a worse prognosis than colorectal cancer patients without ulcerative colitis. These results were published in The American Journal of Gastroenterology. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. ...

Physical Activity May Reduce Deaths from Colorectal Cancer 04/25/2006
According to an article recently published in the journal Gut, patients diagnosed with colorectal cancer who are physically active have significantly lower rates of death from the disease than patients who are not physically active. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. Researchers continue to ...

Telephone Intervention Improves Screening Rates 04/19/2006
According to a study published in the Annals of Internal Medicine, a telephone support intervention improved the rates of screening for breast, cervical, and colorectal cancer among low-income women. Screening for early detection of cancer has improved survival for many types of cancer, including breast, cervical, and colorectal. Cervical and ...

Xeloda®, Eloxatin®, and Tarceva® Effective for Previously Treated Metastatic Colorectal Cancer 04/19/2006
According to an article recently published in the Journal of Clinical Oncology, the treatment combination consisting of Xeloda® (capecitabine), Eloxatin® (oxaliplatin), and Tarceva® (erlotinib) is an effective treatment regimen for patients with metastatic colorectal cancer who have received prior therapies. Colorectal cancer is the second leading cause of cancer-related deaths ...

XELOX is Well Tolerated as Initial Regimen for Elderly Patients with Advanced Colorectal Cancer 04/13/2006
According to an article recently published in the British Journal of Cancer, the chemotherapy combination consisting of capecitabine (Xeloda®) and oxaliplatin (Eloxatin®), known as XELOX, is a well tolerated initial treatment regimen for patients 70 years or older with metastatic colorectal cancer. Colorectal cancer is the second leading cause of ...

Celebrex® Reduces Growth of Colorectal Polyps 04/04/2006
According to a press release from Pfizer, results from two clinical trials suggest that Celebrex® (celecoxib) reduces the growth of precancerous colorectal polyps in patients at increased risk for colorectal cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. The disease develops in the colon ...

Addition of MRI Does Not Improve Colorectal Cancer Follow-Up 04/04/2006
Routine surveillance by magnetic resonance imaging (MRI) was no more effective than conventional follow-up tests in detecting patients with operable colorectal cancer recurrences. These results were published in the Annals of Surgery. Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. The disease develops in the ...

Panitumumab Reduces Disease Progression in Metastatic Colorectal Cancer 04/03/2006
According to results presented at a plenary session at the 97th annual meeting of the American Association for Cancer Research (AACR), the investigative agent panitumumab significantly improved progression-free survival and disease stabilization in patients with metastatic colorectal cancer whose disease had progressed following prior chemotherapy. Colorectal cancer is the second ...

Prognosis Varies Among Patients with T3 Rectal Cancer 03/31/2006
According to a study published in the Annals of Oncology, the prognosis of patients with T3 rectal cancer (cancer that has invaded through the bowel muscle but not into adjacent organs) depends not only on lymph node involvement, but also on how far beyond the muscle the tumor extends. The ...

Erbitux® plus Camptosar® Effective in Patients with Colorectal Cancer Who Have Received Extensive Prior Therapy 03/29/2006
According to article published in the British Journal of Cancer, the treatment combination consisting of Erbitux® (cetuximab) and Camptosar® (irinotecan) provides anticancer activity and may improve outcomes in patients with colorectal cancer who have received two prior therapies. The colon and rectum comprise the final parts of the large intestine. ...

Early Immune Signs Predict Survival in Colorectal Cancer 12/30/2005
According to a recent article published in the New England Journal of Medicine, the presence of an immune response and absence of early signs of cancer spread within a patient's surgically removed cancer specimen is associated with significantly improved cancer-free and overall survival in colorectal cancer. Colorectal cancer remains the second-leading ...

Physical Activity and Healthy Body Weight Improve Colorectal Cancer Survival 12/27/2005
In addition to reducing the risk of developing colorectal cancer, regular physical activity and maintenance of a healthy body weight may improve survival among individuals diagnosed with colorectal cancer. These results were published in the journal Gut. In 2005, the American Cancer Society estimates that there will be 145,000 new ...

No Clear Link Between Dietary Fiber and Colorectal Cancer 12/16/2005
While high fiber intake has been hypothesized to reduce the risk of colorectal cancer, previous studies have produced mixed results. In a large pooled analysis of 13 studies, published in the Journal of the American Medical Association (JAMA), researchers found that dietary fiber was not associated with a reduced ...

Diabetes Linked with Increased Risk of Colorectal Cancer 11/28/2005
A combined analysis of several studies shows evidence of a link between diabetes and colorectal cancer in both men and women, according to a report published in the Journal of the National Cancer Institute . Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. The disease ...

Gemzar®/Cisplatin Appears Promising in Advanced Esophageal Cancer 11/11/2005
According to a recent article published in the British  Journal of Cancer, the treatment combination consisting of chemotherapy agents Gemzar® (gemcitabine) and cisplatin (Platinol®) has significant anticancer activity in patients with advanced, inoperable esophageal cancer. The esophagus is a multi-layered, hollow tube that connects the throat and stomach, allowing transportation ...

Colonoscopy Benefits Those with Family History of Colorectal Cancer 10/28/2005
Screening colonoscopy reduces the risk of colorectal cancer in individuals with a first-degree family history of colorectal cancer, according to a study published in the British Medical Journal . Colorectal cancer is the second leading cause of cancer-related deaths in the US. The disease develops in the large intestine, which ...

Addition of Eloxatin® to Treatment for Unresectable Rectal Cancer Promising 10/27/2005
According to recent results published in the British  Journal of Cancer, the addition of the chemotherapy agent Eloxatin (oxaliplatin) to standard chemotherapy and radiation therapy as initial treatment in locally advanced rectal cancer contributes to promising rates of successful surgical removal of cancer. Rectal cancer is a disease in which ...

Breast Cancer Patients Not at Increased Risk for Colorectal Cancer 10/18/2005
According to a study published in the American Journal of Gastroenterology, women with a history of breast cancer are no more likely than other women to develop colorectal cancer. Breast cancer is the second leading cause of cancer death among women in the US; colorectal cancer is the third. Some ...

Many Patients Not Receiving Recommended Colorectal Cancer Screening 10/18/2005
Only 54% of a large, insured population of patients between the ages of 55 and 70 received recommended colorectal cancer screening during a five-year period, according to a study published in the journal Cancer . Colorectal cancer is the second leading cause of cancer-related deaths in the US. The disease ...

TroVax® Vaccine May Improve Outcomes in Metastatic Colorectal Cancer 10/17/2005
According to results recently presented at the 2005 International Colorectal Cancer Congress, use of the vaccine TroVax® in addition to chemotherapy is safe and may improve outcomes for patients with metastatic colorectal cancer. However, future trials directly comparing TroVax® to chemotherapy alone are necessary to confirm these results. Colorectal cancer ...

COX-2 Expression Associated with Recurrences Following Radiation Therapy in Rectal Cancer 10/12/2005
According to a recent article published in the International Journal of Radiation Oncology, Biology and Physics, patients with rectal cancer that has low expression of cyclooxygenase-2 (Cox-2) have a lower incidence of cancer recurrence near or at the site of origin (local recurrence) following radiation therapy. Conversely, those with ...

Radiation for Rectal Cancer Has Benefit in Spite of Increased Risk of Second Cancers 09/09/2005
According to a study published in the Journal of Clinical Oncology, rectal cancer patients treated with radiation therapy are more likely to develop second cancers, but less likely to have a rectal cancer recurrence, than patients treated with surgery alone. The American Cancer Society estimates that over 40,000 people will ...

Addition of Chemotherapy to Pre-operative Radiation Improves Responses in Rectal Cancer 08/25/2005
According to an article recently published in the Journal of Clinical Oncology, the addition of chemotherapy to pre-operative radiation therapy improves anti-cancer responses in rectal cancer, potentially allowing for greater surgical removal of the cancer. The American Cancer Society estimates that over 40,000 people will be diagnosed with rectal cancer ...

Preliminary Study Indicates that “Statin” Drugs May Improve Response to Chemotherapy and Radiation Therapy in Rectal Cancer 08/04/2005
Researchers have recently published an article in the International Journal of Radiation Oncology Biology and Physics stating that “statin” drugs, those commonly use to treat patients with high cholesterol levels, may improve the response rate to neoadjuvant chemotherapy (chemotherapy given before surgery) in patients with rectal cancer. Rectal cancer is ...

Concurrent Chemotherapy and Radiation Effective for Treatment of Locally Advanced or Recurrent Rectal Cancer 07/25/2005
The Annals of Oncology recently reported that weekly doses of the drugs oxaliplatin (Eloxatin®) and 5-FU given concurrently with radiation therapy shows promising activity for the treatment of locally advanced rectal cancer. Rectal cancer is a disease in which malignant cells arise from the cells of the ...

Erbitux® May Extend the Life of Metastatic Colorectal Cancer Patients 06/21/2005
A recent study reports that the colorectal cancer drug Erbitux® may prolong the life of patients diagnosed with metastatic colorectal cancer. Details of the study were released at the World Congress of Gastrointestinal Cancer in Barcelona, Spain. Colorectal cancer is the second leading cause of cancer-related deaths in the United ...

Further Evidence Indicates Red and Processed Meat Consumption Increases Risk of Colorectal Cancer 06/17/2005
Results recently published in the Journal of the National Cancer Institute indicate that a high intake of red and processed meats increases the risk of colorectal cancer in men and women. These results were similar to evidence found in other studies. The majority of research suggests that a high-fat diet ...

Radiation for Prostate Cancer Increases Risk of Developing Rectal Cancer 04/14/2005
According to a recent article published in Gastroenterology, patients treated with radiation for prostate cancer have a significantly higher risk of developing rectal cancer than patients who undergo surgery for treatment of their prostate cancer. Prostate cancer is the second most commonly diagnosed cancer in men in the United States. ...

Neoadjuvant Camptosar® plus Xeloda® Effective in Rectal Cancer 03/29/2005
The Journal of Clinical Oncology has recently published the results of a study that found that preoperative (neoadjuvant) chemotherapy with Xeloda® (capecitabine) and Camptosar® (irinotecan) is well tolerated and effective for patients with stage 3-4 rectal cancers. Rectal cancer is a disease in which malignant cells arise from the cells ...

P27 Marker May Predict Recurrence in Rectal Cancer 12/07/2004
According to the results of a recent study published in the Annals of Surgical Oncology, measurement of the p27 marker after preoperative chemotherapy and radiation may help predict recurrence-free survival (RFS) in patients with rectal cancer. Rectal cancer is a disease in which malignant cells arise from the cells of ...

Pre-operative Chemoradiotherapy for Rectal Cancer Improves Local Control, but Not Overall Survival 11/03/2004
The results of a recent study published in the New England Journal of Medicine indicate that pre-operative chemoradiotherapy for rectal cancer improved local disease control with reduced toxicity, but did not improve overall survival. Each year in the United States, approximately 140,000 new cases of colorectal cancer are diagnosed. One-third ...

PET/CT Scans Effective In Locating Pelvic Recurrences of Rectal Cancer 09/15/2004
Results of a recent trial published in the journal Radiology indicate that the combined use of PET scans and CT scans is an effective method for detecting pelvic recurrences of rectal cancer. Rectal cancer is a malignancy that arises from the tissues of the rectum. The rectum is the last ...

Statins Associated with Reduced Risk of Colorectal Cancer 06/11/2004
According to results presented at the plenary session at the 40th annual meeting of the American Society of Clinical Oncology (ASCO), the use of the cholesterol-lowering agents called statins may significantly reduce the risk of colorectal cancer. Colorectal cancer is the second leading cause of cancer deaths annually in the ...

Addition of Avastin™ to IFL Chemotherapy Improves Survival in Metastatic Colorectal Cancer 06/07/2004
According to a recent article published in The New England Journal of Medicine, the addition of Avastin™ to the chemotherapy regimen consisting of Camptosar®/5-Fluorouracil/Leucovin (IFL) improves survival compared to IFL alone in metastatic colorectal cancer. Colorectal cancer is the second leading cause of cancer deaths in the United States and ...

Virtual Colonography Not Ready for Clinical Practice 05/07/2004
According to a recent article published in the Journal of the American Medical Association, virtual colonography detected significantly fewer abnormalities of the colon and rectum compared to conventional colonoscopy and does not appear to be ready for the screening of colorectal cancer. Colorectal cancer is the second leading cause of ...

Laparoscopic Surgery Does Not Affect Survival in Colorectal Cancer 05/07/2004
According to an article recently published in The Lancet, laparoscopic surgery does not affect survival compared to conventional surgery for colorectal cancer. Colorectal cancer remains the second leading cause of cancer deaths in the United States. The surgical removal of the cancer remains an integral part of the treatment strategy ...

C-Peptide Associated with Increased Risk of Colorectal Cancer in Men 05/07/2004
According to a recent article published in the Journal of the National Cancer Institute, elevated levels of C-peptide in blood samples is associated with an increased risk of developing colorectal cancer in men. Colorectal cancer is the second leading cause of cancer deaths annually in the United States. If colorectal ...

Genetic Changes Found in Stool Effective Screening for Colorectal Cancer 05/07/2004
According to a recent article published in The Lancet, changes in DNA, referred to as methylation, may be effective as a screening tool for colorectal cancer. Cancers of the colon and rectum, sometimes referred to together as colorectal cancer, begin with the development of an adenomatous polyp, which is a ...

Oral Xeloda® More Convenient with Similar Results to Intravenous 5-FU in Advanced Colorectal Cancer 05/07/2004
According to a recent article published in The British Journal of Cancer, treatment with oral Xeloda® (capecitabine) appears to provide similar results to intravenous 5-fluorouracil plus leucovorin for advanced colorectal cancer while improving convenience of administration for patients and healthcare providers. Colorectal cancer remains the second leading cause of cancer ...

Avastin™ Approved for Treatment of Colorectal Cancer 03/01/2004
The anti-angiogenic agent Avastin™ (bevacizumab) has been approved by the Food and Drug Administration to be used in combination with the chemotherapy regimen 5-fluorouracil/leucovorin as initial treatment for metastatic colorectal cancer. Colorectal cancer is the second leading cause of cancer deaths in the United States, and the American Cancer ...

Intraperitoneal Chemotherapy Improves Survival in Patients with Colorectal Cancer Spread to the Peritoneal Cavity 02/23/2004
According to a recent article published in the British Journal of Cancer, intraperitoneal chemotherapy following the surgical removal of cancer may improve survival compared to intravenous chemotherapy in patients with colorectal cancer that has spread to the peritoneal cavity. The peritoneal cavity is a portion of the abdomen that ...

Capecitabine Plus Irinotecan Appears Promising as Initial Therapy for Metastatic Colorectal Cancer 02/07/2004
According to results presented at the first-ever Gastrointestinal Cancers Symposium, the chemotherapy combination consisting of capecitabine (Xeloda®) and irinotecan (Camptosar®) appears to be a promising treatment regimen as initial therapy for metastatic colorectal cancer. The colon and rectum are the major parts of the large intestine. Metastatic colorectal refers ...

Addition of Avastin™ to 5-FU/LV Improves Progression-Free Survival in Metastatic Colorectal Cancer 12/01/2003
Results from a recent clinical trial indicate that the addition of Avastin™ to the common chemotherapy regimen 5-fluorouracil/leucovorin as initial therapy improves progression-free survival in advanced colorectal cancer. Results from previous clinical trials demonstrated an advantage with the addition of Avastin™ to the chemotherapy regimen Camptosar®/5fluorouracil/leucovorin in the ...

Neoadjuvant Therapy Superior to Adjuvant Therapy in Rectal Cancer 10/28/2003
According to results recently presented at the plenary session of the 2003 annual meeting of the American Society for Therapeutic Radiation and Oncology, neoadjuvant therapy consisting of chemotherapy and radiation appears to be superior to adjuvant therapy in the treatment of locally advanced rectal cancer. The rectum is ...

Surgical Removal of Pulmonary Metastases from Colorectal Cancer Safe and Effective 09/25/2003
According to a recent article published in The Journal of Thoracic and Cardiovascular Surgery, the surgical removal of cancer spread to the lungs from colorectal cancer may provide improved long-term survival in some patients. The colon and rectum are both parts of the large intestine. Colorectal cancer is a ...

Aggressive Therapy Feasible for Patients with Spread of Colorectal Cancer to Liver 09/25/2003
According to a recently published article in the Annals of Oncology, treatment including intravenous chemotherapy plus hepatic artery infusion (HAI) yields a high anti-cancer response rate and is generally well tolerated in patients with colorectal cancer that has spread to the liver. The colon and rectum are both parts ...

Addition of Preoperative Chemotherapy to Radiation Therapy Helps Preserve Sphincter Control for Rectal Cancer Patients 09/11/2003
According to results recently published in the International Journal of Radiation Oncology, Biology and Physics, the addition of chemotherapy to radiation therapy prior to surgery improves anti-cancer responses and helps to preserve sphincter control in patients with rectal cancer. The rectum is the last 8 to 10 ...

Adjuvant 5-FU for Colorectal Cancer Does Not Benefit Patients with High-Frequency Microsatellite Instability 08/04/2003
According to results recently published in The New England Journal of Medicine, a genetic mutation known as microsatellite instability affects responses to the chemotherapy agent 5-fluorouracil (5-FU) in the adjuvant treatment of colorectal cancer. Particularly, patients with high-frequency microsatellite instability do not appear to derive any benefit from ...

Alimta®/Eloxatin® as Initial Therapy for Advanced Colorectal Cancer 07/23/2003
According to results recently presented at the 39th annual meeting of the American Society of Clinical Oncology, the chemotherapy combination consisting of Alimta® (pemetrexed) and Eloxatin® (oxaliplatin) appears active and well tolerated for treatment of advanced colorectal cancer. Colorectal cancer refers to cancers of the colon and rectum, both ...

Cetuximab Re-Sensitizes Patients to Camptosar® in Colorectal Cancer 06/19/2003
According to results recently presented at the 39th annual meeting of the American Society of Clinical Oncology, the addition of cetuximab (Erbitux") to Camptosar® (irinotecan) appears to re-sensitize cancer cells to the effects of Camptosar® and ultimately delays cancer progression in patients with metastatic colorectal cancer who had ...

Avastin™ Plus Chemotherapy Improves Survival in Metastatic Colorectal Cancer 06/09/2003
According to results from a recent clinical trial, the addition of Avastin" (bevacizumab) to chemotherapy improves survival in patients with untreated metastatic colorectal cancer. Cancers of the colon and rectum, often referred to as colorectal cancer, are some of the most common cancers in the United States. When ...

Further Evidence that High-Volume Hospitals Result in Improved Survival for Rectal Cancer Surgery 06/08/2003
According to a recent study published in the Journal of the National Cancer Institute, patients with rectal cancer who are treated at hospitals that perform larger volumes of surgery for rectal cancer have improved outcomes, compared to patients treated at hospitals where fewer of the same procedures are ...

Significantly More Men Up-to-Date on Prostate Screening than Colorectal Screening 04/16/2003
According to a recent article published in the Journal of the American Medical Association, men in the United States are more likely to be up-to-date on their screening for prostate cancer than screening for colorectal cancer. When detected early, colorectal cancer is a highly curable disease. Colorectal cancer typically ...

Glutathione Helps Reduce Side Effects of Oxaliplatin-Based Therapy in Advanced Colorectal Patients 03/18/2003
According to results presented in The Journal of Clinical Oncology, the agent glutathione (GSH) appears to significantly reduce peripheral neuropathy caused by the chemotherapy agent oxaliplatin in patients with advanced colorectal cancer. Oxaliplatin (Eloxatin®) is a chemotherapy agent that is commonly used in the treatment of colorectal cancer ...

Aspirin Reduces Risk of Colorectal Adenomas 03/13/2003
According to two recent clinical trials reported in the New England Journal of Medicine, regular use of aspirin appears to reduce the risk of developing colorectal adenomas. When detected early, colorectal cancer is a highly curable disease. Colorectal cancer begins with the development of an adenomatous polyp (adenoma), ...

Xyotax™ A New Form of Paclitaxel Appears as Effective with Fewer Side Effects 03/11/2003
According to results presented at the EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics, a new form of paclitaxel called Xyotax™ (CT-2103) appears to be just as effective as paclitaxel while producing fewer side effect.1 Paclitaxel (Taxol®) is the most commonly used chemotherapy agent in the world. However, some ...

New Colorectal Screening Method Approved for Human Testing 02/17/2003
Regulatory approval of a new screening method in the detection of recurrent colorectal cancer has recently been announced. The test, called GCC-B1™, is a blood test that has demonstrated great accuracy for the early detection of colorectal cancer that has recurred outside the site of the original ...

High Dietary Folate and Low Alcohol Consumption Linked to Lower Colorectal Cancer 01/23/2003
According to an article recently published in the International Journal of Cancer, a diet rich in folate, including green leafy vegetables, fruits and whole grains, and low in alcohol consumption may lower the risk of developing colorectal cancer. Cancers of the colon and rectum, sometimes referred to together ...

Researchers Evaluate Evidence and Suggest Guidelines for Use of Complementary and Alternative Medicine Therapies 01/22/2003
A recent article published in the Journal of the National Cancer Institute reviewed CAM therapies and evaluation criteria guidelines suggested by several researchers for complementary and alternative medicine (CAM). CAM use by cancer patients has steadily increased throughout the past ten years. While research on CAM has also ...

Radiofrequency Ablation Reduces Local Recurrences Compared to Cryosurgery for Treatment of Inoperable Liver Cancer or Metastasis to the Liver 01/09/2003
According to a recent article published in the Archives of Surgery, radiofrequency ablation appears to be superior to cryosurgery for the treatment of inoperable liver cancer or metastasis to the liver. The liver is the largest organ in the body and is responsible for over 500 functions, including ...

Bevacizumab Improves Long-Term Outcomes in Advanced Colorectal Cancer 01/07/2003
According to a recent article published in the Journal of Clinical Oncology, the addition of bevacizumab (Avastin™) to chemotherapy appears to improve long-term outcomes in patients with newly diagnosed metastatic colorectal cancer. Colorectal cancer affects the colon and rectum, parts of the body's digestive system that together form a ...

Eloxatin®/Camptosar®/5 FU Appears Promising in Metastatic Colorectal Cancer 09/30/2002
According to a recent article published in the Journal of Clinical Oncology, the chemotherapy combination consisting of Eloxatin® (oxaliplatin)/ Camptosar® (irinotecan)/5 FU (5 fluorouracil)/leucovorin (LV) appears promising in the treatment of metastatic and/or recurrent colorectal cancer. The colon and rectum are important parts of the digestive system and ...

Surgery for Lung Metastases may Improve Survival in Patients with Colorectal Cancer After Hepatic Resection 08/27/2002
According to a recent article published in The Cancer Journal, the surgical removal of cancer that has spread (metastases) to the lungs may improve survival in patients with colorectal cancer who have already had surgery to remove metastases to the liver. The colon and rectum comprise the ...

Preoperative Radiation May Improve Survival in Patients with Stage II Rectal Cancer 08/22/2002
According to a recent article published in the Annals of Surgery, preoperative radiation may improve survival in patients with stage II rectal cancer that has not spread to any nearby organs or structures. The rectum comprises approximately the last 10 inches of the colon, or large intestine. Stage II ...

Avicine® Vaccine Produces Immune Responses Against Metastatic Colorectal Cancer 08/13/2002
The results of a recent multi-institutional clinical trial indicate that Avicine® may produce immune responses against colorectal cancer and is easily tolerated by patients. Colorectal cancer affects the colon and rectum, parts of the body's digestive system that together form a long, muscular tube called the large intestine. ...

Eloxatin® (Oxaliplatin) Approved for Colorectal Cancer in the United States 08/13/2002
The Food and Drug Administration approved Eloxatin® (oxaliplatin) for the treatment of colorectal cancer. Eloxatin® is approved to be used in combination with 5-fluorouracil (5-FU)/leucovorin (LV) for advanced colorectal cancer that has progressed or recurred following therapy with Camptosar®/5-FU/LV. 1 Colorectal cancer affects the colon and rectum, parts of the ...

Virtual Colonoscopy Accurately Detects Large Polyps in Colon 08/06/2002
According to a recent article published in the journal Radiology, virtual colonoscopy appears to accurately detect large polyps in the colon. When detected early, colorectal cancer is a highly curable disease. Colorectal cancer typically begins with the development of an adenomatous polyp, which is a small benign tumor ...

Oxaliplatin/Raltitrexed Combination Effective in Metastatic Colorectal Cancer 07/24/2002
According to recent results reported in the Annals of Oncology, the chemotherapy combination oxaliplatin and raltitrexed (Tomudex®)appears to be effective treatment in metastatic colorectal cancer. Colorectal cancer affects the colon and rectum, parts of the body's digestive system that together form a long, muscular tube called the large intestine. ...

Second Surgery for Liver Metastases Safe in Patients with Colorectal Cancer 07/10/2002
According to a recent article published in the Annals of Surgery, patients with colon or rectal cancer can safely and effectively undergo a second surgical removal (resection) of cancer that has spread to the liver. The colon and rectum are important parts of the digestive system. The colon ...

Laparoscopic Colectomy May Improve Outcomes in Colon Cancer 07/08/2002
According to a recent article published in The Lancet, a laparoscopic colectomy may improve outcomes compared to an open colectomy in patients with colon cancer. The colon is an important part of the body’s digestive system, consisting of the last few feet of the large intestine. In patients with ...

Contrast-Enhanced Endorectal MRI More Accurate than Ultrasound in Detecting Residual or Recurrent Rectal Cancer 06/28/2002
According to a recent article published in the German medical journal Rofo-Fortschritte auf dem Gebiet der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, contrast-enhanced endorectal magnetic resonance imaging (EMRI) may be more effective at detecting residual or recurrent cancer than endorectal sonography (ES) in patients who ...

Camptosar®/Oxaliplatin/5-Fluorouracil/Leucovorin Highly Active for Metastatic Colorectal Cancer 06/05/2002
According to results recently published in the Journal of Clinical Oncology, the chemotherapy regimen consisting of Camptosar®, oxaliplatin, 5-fluorouracil and leucovorin appears highly active for the treatment of advanced colorectal cancer. Cancer of the colon or rectum, also referred to as colorectal cancer, is one of the leading causes ...

Oxaliplatin and 5-FU/LV: The New Standard for Treatment of Advanced Colorectal Cancer 05/29/2002
According to results recently presented at the 38th annual meeting of the American Society of Clinical Oncology (ASCO), the chemotherapy regimen consisting of oxaliplatin, 5-FU (fluorouracil) and leucovorin improves survival compared to other standard chemotherapy combinations for the treatment of advanced colorectal cancer. Colorectal cancer affects the colon and ...

Oxaliplatin/Capecitabine Combination Active in Advanced Colon and Rectal Cancer 04/24/2002
According to results recently published in the Journal of Clinical Oncology, the chemotherapy combination consisting of capecitabine and oxaliplatin appears to produce anti-cancer responses in advanced colon and rectal cancer. The colon and rectum are important parts of the body’s digestive system. The colon consists of the last few ...

Early Versus Late Radiation with Concurrent Chemotherapy Appears Superior in Rectal Cancer 04/23/2002
According to an article recently published in the Journal of Clinical Oncology, radiation therapy following surgery delivered early in the course of treatment appears to prolong disease-free survival compared to radiation delivered later in patients with stages II and III rectal cancer. The rectum is the last 8-10 inches ...

St. John’s Wort May Reduce Efficacy of Camptosar® 04/16/2002
According to results recently presented at the annual meeting of the American Association for Cancer Research, the herbal medicine St. Johns wort may reduce the efficacy of the chemotherapy agent Camptosar® when taken together. Camptosar® (irinotecan, CPT-11) is a commonly used chemotherapy agent for the treatment of colorectal cancer ...

Mortality from Some Cancer Surgeries Reduced in Large-Volume Hospitals 04/15/2002
According to a recent article published in The New England Journal of Medicine, death related to surgical procedures (surgical mortality) for some cancers may be significantly reduced if patients receive treatment in hospitals that perform large volumes of the surgical procedure annually. The surgical removal of cancer is ...

Low-Dose Aspirin May Reduce Risk of Pre-Cancerous Colorectal Adenomas 04/10/2002
According to results recently presented at the annual meeting of the American Association for Cancer Research, daily use of low-dose or baby aspirin may reduce the risk of colorectal adenomas. The colon and rectum are important parts of the body’s digestive system. The colon consists of the last few ...

Close Follow-Up Improves Survival in Colorectal Cancer 04/09/2002
According to a recent article published in the British Medical Journal, intensive follow-up after surgery may improve survival rates in patients with colorectal cancer. The colon and rectum are important parts of the body’s digestive system. The colon consists of the last few feet of the large intestine and ...

Women Experience More Side Effects With Fluorouracil-Based Chemotherapy for Colorectal Cancer 03/28/2002
According to a recent article published in the Journal of Clinical Oncology, research indicates that women tend to experience more side effects than men from fluorouracil-based chemotherapy for the treatment of colorectal cancer. The colon and rectum are important parts of the body’s digestive system. The colon consists of ...

New Colorectal Cancer Test Offers Hope for Early Detection 03/04/2002
According to a report in the November issue of the journal Gastroenterology, early detection of colorectal cancer and precancerous tumors may be possible with a new screening test that involves looking for abnormal DNA in stool samples. When detected early, colorectal cancer is a highly curable disease. Colorectal cancer ...

Smoking Linked to an Increased Risk of Colorectal Cancer 02/22/2002
Long-term smoking significantly increases the risk of colorectal cancer, according to a study by American Cancer Society (ACS) researchers that was recently published in the Journal of the National Cancer Institute. Colorectal cancer is not currently on the list of smoking-related cancers, although smoking has consistently been associated with ...

Radiation Plus Surgery Reduces Risk of Recurrences in Rectal Cancer 02/22/2002
Data recently published in The Lancet outlining analysis of over 8,000 patients, suggest that radiation in addition to surgery, either pre or postoperatively, reduces the risk of a local cancer recurrence and death from rectal cancer. Standard treatment of rectal cancer involves surgery and often results in apparent curative ...

Large Trial Confirms that Preoperative Radiation in Rectal Cancer Decreases Recurrences 02/22/2002
Results from a large multi-institutional clinical trial reported in the New England Journal of Medicine provide confirmatory evidence that treatment with pre-operative radiation significantly decreases local cancer recurrences in patients with rectal cancer that has not spread to distant sites and should be considered the standard of care ...

Pre-Operative Radiation Improves Survival in Early Stage Rectal Cancer 02/22/2002
Long-term results recently reported in the journal Cancer indicate that radiation therapy prior to surgery increases survival for patients with early-stage rectal cancer. Cancer of the rectum is characterized by the presence of cancer cells in the rectum, approximately the last 10 inches of the colon (or large bowel), ...

Preoperative Radiation and Chemotherapy May Improve Treatment Outcomes in Patients with Rectal Cancer 02/22/2002
A recent report published in the Journal of Clinical Oncology suggests that pre-operative treatment with radiation therapy and chemotherapy may decrease cancer recurrences, preserve sphincter function and ultimately improve survival in patients with rectal cancer following surgery. Cancer of the anus, the opening at the end of the rectum, ...

Surgery Benefits Selected Elderly Patients with Colorectal Cancer 02/22/2002
Selected elderly patients with colorectal cancer appear to benefit from the surgical removal of cancer, according to a recent article published in The Lancet. Extensive data was analyzed which indicates that elderly patients should not be denied surgery on the sole basis of their age, as they may ...

Preoperative Radiation Therapy is Effective in Intermediate Stage Rectal Cancer 02/22/2002
Patients with rectal cancer, in whom surgery is unable to completely remove the tumor, have a very poor prognosis and are generally considered incurable. There has, therefore, been an increasing interest for treating intermediate to advanced stage rectal cancer with preoperative radiation therapy, with the goal of shrinking ...

Chemo and Radiation Therapy before Surgery for Locally Advanced Rectal Cancer May Help Preserve Bowel Function 02/22/2002
The use of chemotherapy and radiation therapy before surgery for locally advanced cancer of the rectum may allow for a more conservative surgical approach and preservation of bowel function, say researchers from Spain. Cancer of the rectum is characterized by the presence of cancer cells in the rectum, the ...

Radiation Therapy before Surgery for Stages I to III Rectal Cancer Improves Survival 02/22/2002
Many persons with early-stage cancer of the rectum for which all visible cancer can be removed by surgery can be cured. Radiation therapy may be used before or after surgery to help prevent a recurrence (return) of cancer and increase the chance for cure. However, there has been ...

Stage II to III Rectal Cancer: Continuous Infusion May Be More Effective than Intermittent Injection with Fluorouracil 02/22/2002
Fluorouracil may be more effective when given by continuous infusion rather than by short intermittent injections for persons who are also receiving radiation therapy after surgery for stage II or III rectal cancer. According to a recent study, the use of the continuous infusion may result in a ...